Abstract
A novel coronavirus (2019-nCov) was identified in Wuhan, Hubei Province, China in December of 2019. This new coronavirus has resulted in thousands of cases of lethal disease in China, with additional patients being identified in a rapidly growing number internationally. 2019-nCov was reported to share the same receptor, Angiotensin-converting enzyme 2 (ACE2), with SARS-Cov. Here based on the public database and the state-of-the-art single-cell RNA-Seq technique, we analyzed the ACE2 RNA expression profile in the normal human lungs. The result indicates that the ACE2 virus receptor expression is concentrated in a small population of type II alveolar cells (AT2). Surprisingly, we found that this population of ACE2-expressing AT2 also highly expressed many other genes that positively regulating viral reproduction and transmission. A comparison between eight individual samples demonstrated that the Asian male one has an extremely large number of ACE2-expressing cells in the lung. This study provides a biological background for the epidemic investigation of the 2019-nCov infection disease, and could be informative for future anti-ACE2 therapeutic strategy development.
https://www.biorxiv.org/content/10.1101/2020.01.26.919985v1
https://www.biorxiv.org/content/10.1101/2020.01.26.919985v1
"I think this nCov is a binary virus (or Chimeric virus) — “Combining two pathogenic viruses increases the lethality of the new virus”.
To maximize mobility, the weapon should minimize mortality at first. It will look deceptively innocuous for most of its life. But mortality will rise drastically at the end. The average virologist could be baffled by its behaviour because it violates a well-known model."
To maximize mobility, the weapon should minimize mortality at first. It will look deceptively innocuous for most of its life. But mortality will rise drastically at the end. The average virologist could be baffled by its behaviour because it violates a well-known model."
source: https://broward.ghost.io/2020/01/26/binary-virus-conjectures/ a.a.O
True! Should also add that the three cities of Wŭhàn (Wŭchàng, Hànkŏu and Hànchàng) is the central mustering area for the Chinese Central Continental Army and Missile commands.
In my experience from passing through Wŭhàn and street-dining there in 1972, 1976, 1984, 2000 and 2007, that city’s cuicine is not in any way so marked by the eating of strange animals as for instance the Cantonese region.
In my experience from passing through Wŭhàn and street-dining there in 1972, 1976, 1984, 2000 and 2007, that city’s cuicine is not in any way so marked by the eating of strange animals as for instance the Cantonese region.
